Sara Tancredi (Sarah Wayne Callies), Michael's love interest and abettor, overdoses but survives, only to become a pawn in the political conspiracy as she tries to reunite with Michael. He begins his pursuit with a press conference to seek the public's help before taking a closer look at Michael's tattoos, which hold clues about his post-escape plans. Led by Michael Scofield (Wentworth Miller), the mastermind behind the breakout, the escapees endeavor to stay ahead of the manhunt spearheaded by FBI Agent Alexander Mahone (William Fichtner). The second season kicks off with the eight inmates-turned-fugitives facing their first morning outside the walls of the Fox River State Penitentiary.
